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Disponibile posizione di post-dottorato all'Università di San Paolo, Brasile
Postdoctoral Position: Impacts of SlGSNOR manipulation on oxygen and nitrogen reactive species metabolisms and nitrosylated and nitrated protein profiles during tomato fruit ripening.
Department of Botany, Institute of Biosciences, University of São Paulo, Brazil
Abstract: S-Nitrosoglutathione (GSNO), an S-nitrosated derivative of glutathione, plays a central role in nitric oxide (NO) signaling and represents the main NO reservoir in living cells. Endogenous GSNO levels are controlled by the enzyme S-nitrosoglutathione reductase (GSNOR), which catalyzes the reduction of GSNO to oxidized glutathione and ammonium and consequently influences protein S-nitrosylation and cell redox homeostasis. Accumulating evidence indicates that components of the nitroxidative and oxidative metabolisms, cell redox status, as well as S-nitrosylation and nitration events, are involved in the signaling cascades controlling the development and ripening of fleshy fruits. In this context, this project aims to evaluate the impacts of modulating GSNO levels via fruit-specific SlGSNOR silencing or overexpression on the nitroxidative and oxidative metabolisms and the global transcriptional profile of tomato (Solanum lycopersicum) fruits.
General information: Starting time will be September 1st, 2017 (exact date can be negotiated). Full-time position. The initial contract is for 12 months, but it can be extended for few more years. The fellowship is R$ 6,819.30 (approximately 2,000.00 euros) monthly.
Candidate profile: Ph.D. in plant biology or related field within the last three years. Knowledge and experience in molecular biology and biochemistry techniques, statistics, and scientific writing is required. Although not mandatory, previous experience in biochemical and molecular analysis of nitroxidative and/or oxidative metabolisms as well as fruit physiology is desirable. Candidates should be creative and capable of developing a competitive research project while working in autonomy under the supervision of a team leader.
Tasks: The successful candidate is expected to perform original research focused on dissecting the impacts of manipulating GSNO levels on tomato fruit physiology. The candidate will also participate in graduate student project and will supervise undergraduate students.
Application:
Send
a) CV;
b) intention letter (describing your research interests and previous experience in the field);
c) recommendation letter.
To Magdalena Rossi exclusively by email (mmrossi@usp.br) until August 5th, 2017.
(Comunicato dal Prof. Felice Cervone - Dipartimento di Biologia e Biotecnologie "Charles Darwin" - Università di Roma "La Sapienza")